EGGEN

Bart J.L. Eggen

Personal information

name                           Bart J.L. Eggen
born                            December 6, 1965, Heerlen
work address              Department of Neuroscience, section Medical Physiology
Building 3215, room 0869
University of Groningen, University Medical Center Groningen (UMCG)
A. Deusinglaan 1, 9713 AV Groningen, The Netherlands

Education and professional experience

2010-present  Assistant professor, Dept. Neuroscience (section Medical Physiology), UMCG, The Netherlands
2001-2010     Assistant professor, Dept. Developmental Genetics, University of Groningen, The Netherlands
1998-2000      Postdoc, Dept. Developmental Genetics, University of Groningen, The Netherlands (PI: Prof. dr. W. Kruijer)
1997-1998     Postdoc, Laboratory for Molecular Vertebrate Embryology at The Rockefeller University, New York, USA (PI: Prof. dr. A. Hemmati-Brivanlou)
1995-1997     Postdoc, Howard Hughes Medical Institute at the Dept. Neurobiology and Behavior, State University of New York at Stony Brook, USA (PI: Prof. dr. G. Mandel)
1991-1995      PhD degree at the Institute of Molecular Biology and Medical Biotechnology, Dept. Physiological Chemistry, University of Utrecht, The Netherlands. Thesis title: Regulation of B-50/GAP-43 gene expression. (co-)promoters: Dr. L.H. Schrama and Prof. dr. W.H. Gispen
1989-1990      Researcher at the Dept. of Biochemical and Biophysical Sciences, University of Houston, Houston, USA (PI: Prof. dr. J. Eichberg)
1989                Master degree in Medical Biology, University of Utrecht, The Netherlands
1984                VWO, St. Bernardinuscollege, Heerlen

PhD thesis co-promoter

2006      dr. K van der Borght, New neurons in the adult brain; a study on the regulation and function of
neurogenesis in the adult rodent hippocampus (Prof. dr. PG Luiten)
2006      dr. I Plaza-Menacho, Functional analysis of RET in MEN2 (Prof. dr. CHCM Buys)
2007      dr. H Schepers, Aberrant signal transduction and protein expression in acute myeloid leukemia (Prof. dr. E Vellenga)
2009      dr. SM Kooistra, Functional connections between UTF1, chromatin structure and embryonic stem cell pluripotency (Prof. dr. PJM van Haastert)
2010      dr. MM Moreira Alves, Functional and genetic studies in MEN2 and Hirschsprung disease (Prof. dr. RMW Hofstra)
2011      dr. RP Thummer, Characterization and role of UTF1 in embryonic stem and carcinoma cells. Implications for regulation of gene expression, chromatin structure and differentiation (Prof. dr. PJM van Haastert)
2013      dr. V Kannan, Modulation of microglia activity (Prof. dr. HWGM Boddeke)

Research Interest

My research focused on the molecular pathways involved in mammalian development and cancer. Many pathways important for mammalian development are also implicated in oncogenesis, as development requires extensive cellular proliferation and differentiation. Alterations in these processes are common in oncogenesis. In the field of development and cancer, epigenetics has become a prominent research topic, as epigenetics is instrumental for regulation of gene expression profiles, differentiation and proliferation of cells and a critical determinant of cellular identity. Currently, my research is focused on the (epi)genetic regulation of microglia function, in the context of aging and disease.

Teaching

University Teaching Qualification (BKO; 2014)

Lecturer in courses in Biology, Life Sciences and Technology, Medical Sciences, (TOP) Master and Honours College curriculum, both at the Bachelor and Master level
Course topics include: genetics, cell biology, molecular biology and medical biology, stem cells, neuroscience, glia, signal transduction, presentation skills

Lecturer in current courses (both lectures and practicals), including Cell Biology, Genetics, Membrane signaling and Disease, Molecular and Cellular Neuroscience, Stem Cells and Glia Biology and developed 6 new courses (both lectures and practicals; Molecular Genetics and Genomics, Cell Biology 2, Molecular Biology and Medical Biology, Molecular Genetics, Minor congress, and A comprehensive understanding of Stem Cell Biology)

Selected other activities

Member review committee for TOP and ECHO grants, Dutch Organization for Scientific Research (NWO)

Reviewer MRC council grants, UK

Reviewer Veni, Vidi and Vici grant applications Dutch Organization for Scientific Research (NWO)

Reviewer grant applications Dutch Cancer Society KWF

Peer reviewer numerous journals in the fields of stem cells, molecular biology and neuroscience, including Stem Cells, Stem Cell Reports, Glia and British Journal of Pharmacology

Co-founder of Dutch Society for Stem Cell Research, www.dsscr.nl

Organizer 1st & 9th Dutch Stem Cell Meeting (2008, 2014)

Co-organizer 2nd, 3rd, 4th, 5th, 6th, 7th and 8th Dutch Stem Cell Meeting (2009-2015)

Organizer 9th Dutch Chromatin Meeting, 2011

Member Institutional Animal Care and Use Committee (DEC, 2015-present)

Reviewer of textbook Genomes 3, by T.A. Brown, Garland Science

Organized theme Nacht van de Kunst en Wetenschap 2011

Interviewed by Radio Noord, 2014, difference in male/female development

Appearance in talkshow in Stand van Stad, 2015, somatic stem cells in transplantation therapy

Interviewed by Dagblad van het Noorden, 2015, stem cells, promice, state of the art

Publiekslezing BCN, Genetic networks in the brain

Book chapters

1. Boddeke HWGM, Eggen BJ, Biber KP (2013) Cytokine, chemokine and growth factor receptors and signaling. Kettenmann and Ransom (Eds.) Neuroglia, 3rd edition, Chapter 22, Oxford University Press

2. Eggen BJ and Brivanlou AH (1999) BMP antagonists and neural induction. Encyclopedia of Life Sciences

3. Schrama LH, Eggen BJ, De Graan PN, Oestreicher AB, Schotman P, Gispen WH (1994) The neuronal PKC substrate B-50/GAP-43 in plasticity. Canonico PL, Scapagnini U, Pamparana F, Routtenberg A (Eds.) Protein kinase C in the CNS focus on neuronal plasticity, Masson, Milano, 17-29